Incidence of Increased Creatine Kinase and its Effect on Kidney Function in Hand Assisted Laparoscopic Kidney Donors and Their Recipients. Serum creatine kinase was prospectively measured in 74 consecutive patients who underwent hand assisted laparoscopic donor nephrectomy. Creatine kinase elevation occurs in a small but significant number of patients. Operative time was an independent risk factor for increased creatine kinase . Although creatine kinase had no significant effect on short-term creatinine, there was an increase in the percent change in donor creatinine. Finally, the long-term significance of increased creatine kinase without clinical symptoms is unknown. source: The Journal of Urology
Volume 178, Issue 4, October 2007, Pages 1391-1395
Creatine kinase (CK) isoenzymes are essential for storing, buffering and intracellular transport of “energy-rich” phosphate compounds in tissues with fluctuating high energy demand such as muscle, brain and other tissues and cells where Creatine Kinase CK is expressed. Using dividing HeLa cells, we report here for the first time that GM130 and Creatine Kinase BB isoenzyme BB-CK co-localize specifically in a transient fashion during early prophase of mitosis, when GM130 plays an important role in Golgi fragmentation that starts also at early prophase. These data may shed new light on CK BB Isoenzyme BB-CK function for energy provision for Golgi-fragmentation that is initiated by cell signalling cascades in the early phases of mitosis. source:
Institute of Cell Biology HPM D24, ETH ZURICH, Schafmattstr. 18, Zurich, 8093, Switzerland
