Serum levels of troponin and heart-related fraction of creatine kinase (CK-MB) mass are used as diagnostic and prognostic criteria in myocardial infarction , but the relation between those levels and the necropsy-determined size of necrosis has not been tested in human beings.
In this retrospective study, 1-cm-thick transverse sections of the ventricles were cut from the base to the apex in the necropsy hearts of 27 patients aged 47 to 86 years (mean 66, median 69; 19 men). Total and necrotic areas were measured using a computer-linked image analysis system. The weights of the necrotic areas were also calculated.
The correlations of the areas and weights of necrotic myocardium with the highest serum values of CK-MB mass and troponin I, which had been quantified during life by chemiluminescence immunoassays, were verified by Pearson's test; results were considered significant at p <=0.05.
Significant correlations were detected between Creatine Kinase isoenzyme mb (CK-MB) mass peak and infarct size (r = 0.63, p <0.01) and weight (r = 0.69, p <0.01) and between CK-MB mass and highest troponin level (r = 0.73, p <0.01); however, the correlations between highest troponin level and myocardial infarct size (r = 0.31, p = 0.11) and weight (r = 0.35, p = 0.07) were small and nonsignificant.
In conclusion, despite the well-established role of serum levels of troponin as a diagnostic tool for myocardial infarction, their highest values showed poor correlations with the extent of infarct. In contrast, the highest serum level of CK-MB mass was well correlated with myocardial infarct size.
Costa TN, Cassaro Strunz CM, Nicolau JC, Gutierrez PS.
Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Am J Cardiol. 2008 Feb 1;101(3):311-4.
Tuesday
Wednesday
New physiological model of serum creatine phosphokinase activity in acute myocardial infarction
In this report, we introduce a new physiological model of the serum creatine phosphokinase (CPK) activity change, that is useful for estimating the total CPK release accurately even with reduced blood sampling frequency. The physiological model was applied to the serum creatine kinase CPK activity change of patients who suffered acute myocardial infarction (AMI), and the model showed good agreement with the serum CPK activity. In addition, the calculated value of total CPK release agreed well with that calculated using the conventional technique.
Faculty of Health Sciences, Okayama University Graduate School, 2-5-1 Shikata, Okayama-shi, Okayama, JAPAN,Conf Proc IEEE Eng Med Biol Soc. 2007;1:912-5,Kitawaki T, Oka H, Kusachi S, Himeno R.
Faculty of Health Sciences, Okayama University Graduate School, 2-5-1 Shikata, Okayama-shi, Okayama, JAPAN,Conf Proc IEEE Eng Med Biol Soc. 2007;1:912-5,Kitawaki T, Oka H, Kusachi S, Himeno R.
Friday
Creatine Kinase levels
Abstract: Creatine Kinase levels in unmedicated bipolar patients
Various reports have described increased serum creatine kinase (CK) activity in the majority of hospitalized acutely disturbed schizophrenics and patients with affective psychoses. We investigated creatine kinase serum levels of 52 unmedicated bipolar inpatients, in manic versus depressive states.
Additional 17 patients were evaluated in both states. Hamilton Rating Scale for Depression and Young Mania Rating Scale were used and blood samples were obtained from new admitted patients. Higher creatine kinase level was found in the manic patients compared with the depressed ones.
Likewise, the creatine kinase level was higher in the manic phase than in the depressive one, when tested within the same patient.
Our results suggest that the clinical differences between mania and depression states are supported by contrasting levels of creatine kinase CK . The lack of correlations between creatine kinase level and motor items suggest that creatine kinase CK level in mania versus depression could emphasize the “thinking speed” and not the motor one.
European Neuropsychopharmacology
Volume 17, Issue 12, December 2007, Pages 763-767
i:10.1016/j.euroneuro.2007.04.007
Tel Aviv University, Tel Aviv, Israel
Various reports have described increased serum creatine kinase (CK) activity in the majority of hospitalized acutely disturbed schizophrenics and patients with affective psychoses. We investigated creatine kinase serum levels of 52 unmedicated bipolar inpatients, in manic versus depressive states.
Additional 17 patients were evaluated in both states. Hamilton Rating Scale for Depression and Young Mania Rating Scale were used and blood samples were obtained from new admitted patients. Higher creatine kinase level was found in the manic patients compared with the depressed ones.
Likewise, the creatine kinase level was higher in the manic phase than in the depressive one, when tested within the same patient.
Our results suggest that the clinical differences between mania and depression states are supported by contrasting levels of creatine kinase CK . The lack of correlations between creatine kinase level and motor items suggest that creatine kinase CK level in mania versus depression could emphasize the “thinking speed” and not the motor one.
European Neuropsychopharmacology
Volume 17, Issue 12, December 2007, Pages 763-767
i:10.1016/j.euroneuro.2007.04.007
Tel Aviv University, Tel Aviv, Israel
CREATINE KINASE LATEST RESEARCH
Incidence of Increased Creatine Kinase and its Effect on Kidney Function in Hand Assisted Laparoscopic Kidney Donors and Their Recipients. Serum creatine kinase was prospectively measured in 74 consecutive patients who underwent hand assisted laparoscopic donor nephrectomy. Creatine kinase elevation occurs in a small but significant number of patients. Operative time was an independent risk factor for increased creatine kinase . Although creatine kinase had no significant effect on short-term creatinine, there was an increase in the percent change in donor creatinine. Finally, the long-term significance of increased creatine kinase without clinical symptoms is unknown. source: The Journal of Urology
Volume 178, Issue 4, October 2007, Pages 1391-1395
Creatine kinase (CK) isoenzymes are essential for storing, buffering and intracellular transport of “energy-rich” phosphate compounds in tissues with fluctuating high energy demand such as muscle, brain and other tissues and cells where Creatine Kinase CK is expressed. Using dividing HeLa cells, we report here for the first time that GM130 and Creatine Kinase BB isoenzyme BB-CK co-localize specifically in a transient fashion during early prophase of mitosis, when GM130 plays an important role in Golgi fragmentation that starts also at early prophase. These data may shed new light on CK BB Isoenzyme BB-CK function for energy provision for Golgi-fragmentation that is initiated by cell signalling cascades in the early phases of mitosis. source:
Institute of Cell Biology HPM D24, ETH ZURICH, Schafmattstr. 18, Zurich, 8093, Switzerland
Volume 178, Issue 4, October 2007, Pages 1391-1395
Creatine kinase (CK) isoenzymes are essential for storing, buffering and intracellular transport of “energy-rich” phosphate compounds in tissues with fluctuating high energy demand such as muscle, brain and other tissues and cells where Creatine Kinase CK is expressed. Using dividing HeLa cells, we report here for the first time that GM130 and Creatine Kinase BB isoenzyme BB-CK co-localize specifically in a transient fashion during early prophase of mitosis, when GM130 plays an important role in Golgi fragmentation that starts also at early prophase. These data may shed new light on CK BB Isoenzyme BB-CK function for energy provision for Golgi-fragmentation that is initiated by cell signalling cascades in the early phases of mitosis. source:
Institute of Cell Biology HPM D24, ETH ZURICH, Schafmattstr. 18, Zurich, 8093, Switzerland
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