New physiological model of serum creatine phosphokinase activity in acute myocardial infarction

In this report, we introduce a new physiological model of the serum creatine phosphokinase (CPK) activity change, that is useful for estimating the total CPK release accurately even with reduced blood sampling frequency. The physiological model was applied to the serum creatine kinase CPK activity change of patients who suffered acute myocardial infarction (AMI), and the model showed good agreement with the serum CPK activity. In addition, the calculated value of total CPK release agreed well with that calculated using the conventional technique.

Faculty of Health Sciences, Okayama University Graduate School, 2-5-1 Shikata, Okayama-shi, Okayama, JAPAN,Conf Proc IEEE Eng Med Biol Soc. 2007;1:912-5,Kitawaki T, Oka H, Kusachi S, Himeno R.


Creatine Kinase levels

Abstract: Creatine Kinase levels in unmedicated bipolar patients
Various reports have described increased serum creatine kinase (CK) activity in the majority of hospitalized acutely disturbed schizophrenics and patients with affective psychoses. We investigated creatine kinase serum levels of 52 unmedicated bipolar inpatients, in manic versus depressive states.

Additional 17 patients were evaluated in both states. Hamilton Rating Scale for Depression and Young Mania Rating Scale were used and blood samples were obtained from new admitted patients. Higher creatine kinase level was found in the manic patients compared with the depressed ones.

Likewise, the creatine kinase level was higher in the manic phase than in the depressive one, when tested within the same patient.

Our results suggest that the clinical differences between mania and depression states are supported by contrasting levels of creatine kinase CK . The lack of correlations between creatine kinase level and motor items suggest that creatine kinase CK level in mania versus depression could emphasize the “thinking speed” and not the motor one.

European Neuropsychopharmacology
Volume 17, Issue 12, December 2007, Pages 763-767
Tel Aviv University, Tel Aviv, Israel


Incidence of Increased Creatine Kinase and its Effect on Kidney Function in Hand Assisted Laparoscopic Kidney Donors and Their Recipients. Serum creatine kinase was prospectively measured in 74 consecutive patients who underwent hand assisted laparoscopic donor nephrectomy. Creatine kinase elevation occurs in a small but significant number of patients. Operative time was an independent risk factor for increased creatine kinase . Although creatine kinase had no significant effect on short-term creatinine, there was an increase in the percent change in donor creatinine. Finally, the long-term significance of increased creatine kinase without clinical symptoms is unknown. source: The Journal of Urology
Volume 178, Issue 4, October 2007, Pages 1391-1395

Creatine kinase (CK) isoenzymes are essential for storing, buffering and intracellular transport of “energy-rich” phosphate compounds in tissues with fluctuating high energy demand such as muscle, brain and other tissues and cells where Creatine Kinase CK is expressed. Using dividing HeLa cells, we report here for the first time that GM130 and Creatine Kinase BB isoenzyme BB-CK co-localize specifically in a transient fashion during early prophase of mitosis, when GM130 plays an important role in Golgi fragmentation that starts also at early prophase. These data may shed new light on CK BB Isoenzyme BB-CK function for energy provision for Golgi-fragmentation that is initiated by cell signalling cascades in the early phases of mitosis. source:
Institute of Cell Biology HPM D24, ETH ZURICH, Schafmattstr. 18, Zurich, 8093, Switzerland