In this report, we introduce a new physiological model of the serum creatine phosphokinase (CPK) activity change, that is useful for estimating the total CPK release accurately even with reduced blood sampling frequency. The physiological model was applied to the serum creatine kinase CPK activity change of patients who suffered acute myocardial infarction (AMI), and the model showed good agreement with the serum CPK activity. In addition, the calculated value of total CPK release agreed well with that calculated using the conventional technique.
Faculty of Health Sciences, Okayama University Graduate School, 2-5-1 Shikata, Okayama-shi, Okayama, JAPAN,Conf Proc IEEE Eng Med Biol Soc. 2007;1:912-5,Kitawaki T, Oka H, Kusachi S, Himeno R.