Creatine Kinase levels

Abstract: Creatine Kinase levels in unmedicated bipolar patients
Various reports have described increased serum creatine kinase (CK) activity in the majority of hospitalized acutely disturbed schizophrenics and patients with affective psychoses. We investigated creatine kinase serum levels of 52 unmedicated bipolar inpatients, in manic versus depressive states.

Additional 17 patients were evaluated in both states. Hamilton Rating Scale for Depression and Young Mania Rating Scale were used and blood samples were obtained from new admitted patients. Higher creatine kinase level was found in the manic patients compared with the depressed ones.

Likewise, the creatine kinase level was higher in the manic phase than in the depressive one, when tested within the same patient.

Our results suggest that the clinical differences between mania and depression states are supported by contrasting levels of creatine kinase CK . The lack of correlations between creatine kinase level and motor items suggest that creatine kinase CK level in mania versus depression could emphasize the “thinking speed” and not the motor one.

European Neuropsychopharmacology
Volume 17, Issue 12, December 2007, Pages 763-767
Tel Aviv University, Tel Aviv, Israel